The Comprehensive Female Profile II is a bloodspot dominant, multiple hormone function test.
The Comprehensive Female Profile II provides an alternative to the Comprehensive Female Profile I by being more bloodspot dominant.
Various hormone concentrations are vital makers for a woman’s health and development. This test provides a quantitative perspective of a woman’s hormone functions.
Female hormone function
Saliva tests: Cx4
Blood spot tests: E2, Pg, T, SHBG, DS, fT4, fT3, TSH, TPO
Estradiol and progesterone levels and their ratio are an index of estrogen/progesterone balance. An excess of estradiol, relative to progesterone, can explain many symptoms in reproductive age women including endometrial hyperplasia, pre-menstrual syndrome, fibrocystic breasts, and uterine fibroids. In older women using estrogen supplements alone, a deficiency in progesterone can also result in symptoms of estrogen dominance, which include weight gain in the hips and thighs, fibrocystic and tender breasts, uterine fibroids, irritability, water retention, and thyroid problems. These symptoms are also seen in some women approaching menopause, whose estrogen levels swing wildly from high to low without the balancing effects of progesterone. If estrogen dominance is not corrected, it can lead to cancers of the uterus and breasts, and insulin resistance. With the onset of menopause, when ovarian estrogen and progesterone production declines, a new subset of symptoms can result from low estradiol levels, including hot flashes, night sweats, vaginal dryness, sleep disturbances, foggy thinking, more rapid skin aging, and bone loss. Maintaining appropriate levels of estradiol, adequately balanced with progesterone, at any age is essential for optimal health.
Testosterone levels can also be either too high or too low. Testosterone in excess, often caused by ovarian cysts, leads to conditions such as excessive facial and body hair, acne, and oily skin and hair. Polycystic ovarian syndrome (PCOS) is thought to be caused, in part, by insulin resistance. On the other hand, too little testosterone is often caused by excessive stress, medications, contraceptives, and surgical removal of the ovaries. This leads to symptoms of androgen deficiency including loss of libido, thinning skin, vaginal dryness, loss of bone and muscle mass, depression, and memory lapses.
SHBG is a protein produced by the liver in response to exposure to any type of estrogen, whether produced naturally by the body, consumed as a synthetic oral contraceptive estrogen, estrogen therapy, or as foods or herbs (phytoestrogens). Released from the liver into the bloodstream, SHBG binds tightly to circulating estradiol and testosterone, preventing their rapid metabolism and clearance and limiting their bioavailability to tissues. SHBG gives a good index of the extent of the body’s overall exposure to estrogens. The SHBG level is also used to calculate free (unbound) testosterone levels when blood spot is used instead of saliva to measure sex hormones.
DHEA, mostly found in the circulation in its conjugated form, DHEA sulfate (DHEA-S), is a hormone produced by the adrenal glands, and levels generally reflect adrenal gland function. It is a precursor for the production of estrogens and testosterone, and is therefore normally present in greater quantities than all the other steroid hormones. Its production is highest in the late teens to early 20s, and declines gradually with age. Like cortisol, it is involved with immune function and a balance between the two is essential. Low DHEA can result in reduced libido and general malaise, while high DHEA can have masculinizing effects on women because it metabolizes to androgens, including testosterone. Because of its conversion to estrogens and androgens, it is important to monitor levels of these hormones, as well as levels of DHEA, during supplementation.
Cortisol is an indicator of adrenal function and exposure to stressors. Under normal circumstances, adrenal cortisol production shows a diurnal variation and is highest early in the morning, soon after waking, falling to lower levels in the evening. Normal cortisol production shows a healthy ability to respond to stress. Low cortisol levels can indicate adrenal fatigue (a reduced ability to respond to stressors), and can leave the body more vulnerable to poor blood sugar regulation and immune system dysfunction. Chronically high cortisol is a consequence of high, constant exposure to stressors, and this has serious implications for long-term health, including an increased risk of cancer, osteoporosis, and possibly Alzheimer’s disease.
The Thyroid Profile (free T4, free T3, TSH, and TPO) can indicate the presence of an imbalance in thyroid function, which can cause a wide variety of symptoms, including feeling cold all the time, low stamina, fatigue (particularly in the evening), depression, low sex drive, weight gain, and high cholesterol. Thyroid deficiency can also be a cause of infertility, which is why these tests are included in the Female Fertility Profiles.
LH and FSH tests are included in the Female Fertility Profiles to give information on the possible presence of ovarian insufficiency (elevated FSH) or PCOS (elevated LH/FSH).